Insulin-like growth factor signaling axis is believed to play a key role in the progression of prostate cancer. It consists of two ligands (
and), two receptors (IGF-IR and IGF-IIR) and six related high affinity IGF-binding proteins (IGFBP 1-6). Altered expression of members of the IGF axis has been implicated in the development of various types of cancers, including prostate cancer. Derivatives is under investigation for prostate cancer. is in phase III trials for HRPC (chemotherapy and after chemotherapy patient groups). [Scientists have found a few of prostate cancer to investigate the mechanism involved in the progression of prostate cancer. , PC-3 (
) and DU-145 (
) are commonly used prostate cancer cell lines. LNCaP cell cancer line was installed from a human lymph node metastases of adenocarcinoma of the prostate. PC-3 and DU-145 cells were established from human prostate adenocarcinoma metastatic to bone and brain, respectively. LNCaP cells express
(AR), however, PC-3 and DU-145 cells express very little or no AR. AR, androgen-activated owned steroids
family. The development of the prostate depends on androgen signaling mediated by AR, and AR is also important during the development of prostate cancer. Distribution of LNCaP cells
-dependent but the proliferation of PC-3 and DU-145 cells insensitive. Height AR expression is often observed in advanced prostate
patients. Some androgen-independent LNCaP sublines have been developed for the levaquin no prescription ATCC androgen-dependent LNCaP cells after androgen to study the progression of prostate cancer.
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